![]() ![]() Analogously, in the context of HSC transplantation (HSCT), the immune system development starts de novo from the donor HSCs. Indeed, the effects of GC exposure during the perinatal period become evident in the adulthood. During the development of an organism, this regulation has long-term consequences. Glucocorticoids (GCs) and sex hormones not only regulate immune responses, but also control the hematopoietic stem cell (HSC) differentiation and subsequent maturation of immune cell subsets. Through the release of hormones, the neuro-endocrine system regulates the immune system function promoting adaptation of the organism to the external environment and to intrinsic physiological changes. ![]() Department of Immunology, IRCCS Bambino Gesù Children’s Hospital, Rome, Italy.Linda Quatrini * Biancamaria Ricci Cecilia Ciancaglini Nicola Tumino Lorenzo Moretta
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